Selected Peer-Review Publications, Patents, and Presentations from NAP Scientific Leadership:

1. Justice A, Kirk RD, Manning A, Roggen M, & Miyabe Shields C (2025) Impact of Water Activity on the Chemical Composition of Smoking Quality of Cannabis Flower: The Science of Smokability Phase I Results. Cannabis Science and Technology.

2. Jouaneh, T. M., Morrison, J. J., Luthern, A. C., Kirk, R. D., Camberg, J. L., & Bertin, M.J. (2025). In Vitro Reversal of Escherichia coli Quiescence by Catechol-Containing Polyphenols and Phenolic Acids Across Multiple Strains. Nutraceuticals.

3. Roche, K.M., Church, I.N., Sterling, A.R., Rynearson, T.A., Bertin, M.J., Kim, A.M., Kirk, R.D., Jenkins, B.D. (2024) Connectivity of toxigenic Pseudo-nitzschia species assemblages between the Northeast U.S. continental shelf and an adjacent estuary. Harmful Algae.

4. Via, C.W., Grauso, L., McManus, K.M., Kirk, R.D., Kim, A.M., Webb, E.A., Held, N.A., Saito, M.A., Scarpato, S., Zimba, P.V., Moeller, P.D.R., Mangoni, A., Bertin,M.J. (2024) Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-Ocean Trichodesmium thiebautii as a Talented Producer of Specialized Metabolites. Environmental Science & Technology.

5. Kirk, R.D., Miyabe Shields C.,. Dautrich, T., and Provost, K. (2023) Introducing the Daily Cannabis Consumer Neurotype, a neurodiversity- affirming evaluation of complex medical cannabis patients. Presented at MCR Labs Science Fair at Harvard. Cambridge, MA.

6. Kirk RD, Lehfeldt P, and Miyabe Shields C (2023) Minor Cannabinoids for the Treatment of Anxiety During the COVID-10 Pandemic: A Case Report. The American Journal for Endocannabinoid Medicine.

7. Canals PC, Aguilar AG, Carter GT, Miyabe Shields C, Westerkamp A, D’Ella M, et al. (2023) Patient Reported Outcomes Using Medical Cannabis for Managing Pain in Charcot-Marie-Tooth Disease. American Journal of Hospice and Palliative Medicine.

8. Kirk RD, Uhley OM, Lehfeldt P, Miyabe Shields C, Garretson M, Collins A, Wahbeh H, and Dahmer S. (2023) Willingness to Participate in Entheogen Use Research in Naturalistic Settings. Journal of Psychedelic Studies.

9. Malamas MS, Lamani M, Farah SI, Mohammad KA, Miyabe Shields C, Rajarshi G, Wu S, Zvonok K, Chandrashekhar H, WOod J, and Makriyannis A. (2023) Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors. ChemMedChem - The European Chemical Society.

10. Miyabe C and Kirk RD (2022) Chapter 6: Pharmaceutical Applications of Hemp Cannabis sativa.” Revolutionizing the Potential of Hemp and its Products in Changing the Global Economy. Springer Publishing

11. Kirk, R.D., Akanji, T.A., Huifang, L., Ma, H., Bertin, M.B., Seeram, N.S. (2021) An in vitro investigation into the stability and permeability of Cannabidiol through artificial skin membranes. Journal of Cannabis and Cannabinoid Research.

12. Sterling, A.R., Kirk, R.D., Bertin, M.J., Rynearson, T.A., Borkman, D.G., Caponi, M.C., Carney, J., Hubbard, K.A., King, M.A., Maranda, L., McDermith, E.J., Santos, N.R., Strock, J.P., Tully, E.M., Vaverka, S.B., Wilson, P.D., Jenkins, B.D. (2022) Emerging harmful algal blooms caused by distinct seasonal assemblages of a toxic diatom. Limnology and Oceanography.

13. Kirk, R.D., Rosario, M.E., Oblie, N., Jouaneh, T.M.M., Carro, M.A., Wu, C., Kim, A.M., Leibovitz, E., Hunter, E.S., Literman, R., Handy, S.M., Rowley, D.C., Bertin, M.J. (2022) Screening the PRISM library against Staphylococcus aureus reveals a sesquiterpene lactone from Liriodendron tulipifera with inhibitory activity. ACS Omega.

14. Miyabe Shields C and Westerkamp A (2021) US PATENT PCT/US2021/012778. “Methods for Obtaining Compounds from a Plant or Fungus Material, Respective Compositions, and Uses Thereof.” Filed 2021, granted 2022.

15. Kirk, R.D., Akanji, T.A., Huifang, L., Ma, H., Bertin, M.B., Seeram, N.S. (2021) An in vitro investigation into the stability and permeability of Cannabidiol through artificial skin membranes. Journal of Cannabis and Cannabinoid Research.

16. Kirk, R.D., Carter, G.T., Bertin, M.J. (2021). New Micropeptins with Anti- neuroinflammatory Activity Isolated from a Cyanobacterial Bloom. ACS Omega.

17. Malamas MS, Farah SI, Lamani M, Pelekoudas DN, Perry NT, Rajarshi G, Miyabe C, Chandrashekhar H, West J, Pavlopoulos S, and Makriyannis A. (2020). “Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors.” Bioorganic & Medicinal Chemistry.

18. Kirk, R.D., Carro, M.A., Wu, C., Jamal, M., Wharton, A.M., Goldstein, D.G., Rosario, M.E., Gallucci, G.M., Zhao Y., Leibovitz E., Bertin, M.J. (2020) Integrating Natural Product Chemistry Workflows into Medicinal Chemistry Laboratory. Journal of Chemical Education.

19. Kirk, R.D., Picard, K.S., Christian, J.C., Johnson, S.J., DeBoef, B., Bertin, M.J. (2020) Unnarmicin D, an Anti-inflammatory Cyanobacterial Metabolite with Delta and Mu Opioid Binding Activity Discovered via a Pipeline Approach Designed to Target Neurotherapeutics. ACS Neuroscience.

20. Liu, C., Xu, Y., Kirk, R.D., Beritn, M.J., Seeram N.P. (2020) Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes. Journal of Functional foods.

21. McManus, K.M., Kirk, R.D., Via, C.W., Lotti, J.S., Roduit, A.F., Teta, R., Scarpato, S., Mangoni, A., Bertin, M.J. (2020) Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of Trichodesmium thiebautii. Journal of Natural Products.

22. Alapafuja SO., Malamas MS, Shukla V, Zvonok A, Miller S, Daily L, Rajarshi G, Miyabe C, Chandrashekhar H, Wood J, Tyukhtenko S, Straiker A, and Makriyannis A. (2019). Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & Medicinal Chemistry.

23. Miyabe Shields C, Zvonok N, and Makriyannis A. (2019). “Expression, Purification, and Proteomic Characterization of Human α/β Hydrolase Domain 6.” Scientific Reports.

24. Johnson S.L., Kirk, R.D., DaSilva N.A., Ma H., Seeram N.P., Bertin M.J. (2019). Polyphenol Metabolites Exhibit Gut and Blood- Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation. Metabolites.

25. Ulu A, Lee KS, Miyabe C, Yang J, Hammock GB, Dong H, Hammock BD. (2014). “An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension.” Journal of Cardiovascular Pharmacology.

26. Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. (2013). “Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension.” Journal of Cardiovascular Pharmacology.